DISEASES

Disease-gene associations mined from literature

JensenLab

Human genes for hypomyelinating leukodystrophy 8

Hypomyelinating leukodystrophy 8 [DOID:0060797]

A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of early childhood onset of cerebellar ataxia, mild intellectual disabilities associated with diffuse hypomyelination and variable development of oligodontia and/or hypogonadotropic hypogonadism that has_material_basis_in compound heterozygous mutation in the POLR3B gene on chromosome 12q23.

Synonyms:  hypomyelinating leukodystrophy 8,  DOID:0060797,  HLD8