DISEASES

Disease-gene associations mined from literature

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Human genes for paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria [DOID:0060284]

An aquired hemolytic anemia that is characterized by abdominal pain, hematuria, esophageal dysmotility and thrombosis, has_material_basis_in defect in the cell membrane glycosyl phosphatidylinositols that protect red blood cells from the innate complement immune system.

Synonyms:  paroxysmal nocturnal hemoglobinuria,  DOID:0060284,  paroxysmal nocturnal hemoglobinurias

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.