DISEASES

Disease-gene associations mined from literature

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Human genes for polycythemia vera

Polycythemia vera [DOID:8997]

Polycythemia vera (also known as erythremia, or primary polycythemia) is a myeloproliferative blood disorder in which the bone marrow makes too many red blood cells. It may also result in the overproduction of white blood cells and platelets. Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. It is more common in the elderly and may be symptomatic or asymptomatic.

Synonyms:  polycythemia vera,  DOID:8997,  Erythremia (morphologic abnormality),  Osler-Vaquez syndrome,  Polycythaemia rubra vera ...

The disease associations are derived via automatic text mining of the biomedical literature and have not been manually verified. The confidence of each association is signified by stars, where ★★★★☆ is the highest confidence and ★☆☆☆☆ is the lowest.

Each disease–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Sune Frankild and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.