DISEASES

Disease-gene associations mined from literature

Human genes for cervix uteri carcinoma in situ

Cervix uteri carcinoma in situ [DOID:8991]

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia and cervical interstitial neoplasia, is the potentially premalignant transformation and abnormal growth (dysplasia) of squamous cells on the surface of the cervix. CIN is not cancer, and is usually curable. Most cases of CIN remain stable, or are eliminated by the host's immune system without intervention. However a small percentage of cases progress to become cervical cancer, usually cervical squamous cell carcinoma (SCC), if left untreated. The major cause of CIN is chronic infection of the cervix with the sexually transmitted human papillomavirus (HPV), especially the high-risk HPV types 16 or 18. Over 100 types of HPV have been identified. About a dozen of these types appear to cause cervical dysplasia and may lead to the development of cervical cancer. Other types cause warts.

Synonyms:  cervix uteri carcinoma in situ,  DOID:8991,  CIN III,  CIN III - carcinoma in situ of cervix,  CIN III - severe dyskaryosis ...