DISEASES

Disease-gene associations mined from literature

Human genes for malignant hyperthermia

Malignant hyperthermia [DOID:8545]

Malignant hyperthermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to certain drugs used for general anesthesia; specifically, the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature, eventually leading to circulatory collapse and death if not treated quickly.

Synonyms:  malignant hyperthermia,  DOID:8545,  anesthesia related hyperthermia,  malignant hyperpyrexia due to anesthesia