DISEASES

Disease-gene associations mined from literature

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Human genes for malignant peripheral nerve sheath tumor

Malignant peripheral nerve sheath tumor [DOID:5940]

A malignant peripheral nerve sheath tumor (also known as "Malignant schwannoma," "Neurofibrosarcoma," and "Neurosarcoma") is a form of cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classified as a sarcoma. About half the cases are diagnosed in people with neurofibromatosis; the lifetime risk for an MPNST in patients with neurofibromatosis type 1 is 8-13%. MPNST with rhabdomyoblastomatous component are called Malignant triton tumors.

Synonyms:  malignant peripheral nerve sheath tumor,  DOID:5940,  malignant neoplasm of the peripheral nerve Sheath,  malignant peripheral nerve sheath tumor (disorder),  malignant peripheral nerve sheath tumor (morphologic abnormality) ...

The disease associations are derived via automatic text mining of the biomedical literature and have not been manually verified. The confidence of each association is signified by stars, where ★★★★☆ is the highest confidence and ★☆☆☆☆ is the lowest.

Each disease–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Sune Frankild and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.