DISEASES

Disease-gene associations mined from literature

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Human genes for central retinal vein occlusion

Central retinal vein occlusion [DOID:2450]

The central retinal vein is the venous equivalent of the central retinal artery, and like that blood vessel can suffer from occlusion (central retinal vein occlusion), similar to that seen in ocular ischemic syndrome. Since the central retinal artery and vein are the sole source of blood supply and drainage for the retina, such occlusion can lead to severe damage to the retina and blindness, due to ischemia (restriction in blood supply) and edema (swelling).

Synonyms:  central retinal vein occlusion,  DOID:2450,  central retinal vein occlusion (disorder),  central retinal vein occlusion disorder,  central retinal vein occlusion

The disease associations are derived via automatic text mining of the biomedical literature and have not been manually verified. The confidence of each association is signified by stars, where ★★★★☆ is the highest confidence and ★☆☆☆☆ is the lowest.

Each disease–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Sune Frankild and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.