DISEASES

Disease-gene associations mined from literature

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Human genes for hemorrhagic disease

Hemorrhagic disease [DOID:2213]

In medicine (hematology), bleeding diathesis (or bleeding tendency or predisposition or haemorrhagic diatheses) is an unusual susceptibility to bleeding (hemorrhage) mostly due to hypocoagulability, in turn caused by a coagulopathy (a defect in the system of coagulation). Several types are distinguished, ranging from mild to lethal. Also, bleeding diathesis can be caused by thinning of the skin or impaired wound healing.

Synonyms:  hemorrhagic disease,  DOID:2213,  hemorrhagic disorder,  hemorrhagic syndrome,  Hemorrhagic diathesis

The disease associations are derived via automatic text mining of the biomedical literature and have not been manually verified. The confidence of each association is signified by stars, where ★★★★☆ is the highest confidence and ★☆☆☆☆ is the lowest.

Each disease–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Sune Frankild and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.