Disease-gene associations mined from literature

Human genes for dental caries

Dental caries [DOID:216]

Dental caries, also known as tooth decay or a cavity, is an infection usually bacterial in origin that causes demineralization of the hard tissues (enamel, dentin and cementum) and destruction of the organic matter of the tooth, usually by production of acid by hydrolysis of the food debris accumulated on the tooth surface . If demineralization exceeds saliva and other remineralization factors such as from calcium and fluoridated toothpastes, these tissues progressively break down, producing dental caries (cavities, holes in the teeth). Two groups of bacteria are responsible for initiating caries: Streptococcus mutans and Lactobacillus. If left untreated, the disease can lead to pain, tooth loss and infection. Today, caries remains one of the most common diseases throughout the world. Cariology is the study of dental caries.

Synonyms:  dental caries,  DOID:216,  Dental caries extending into pulp,  Dental caries of smooth surface,  Dental caries pit and fissure