DISEASES

Disease-gene associations mined from literature

Human genes for WAGR syndrome

WAGR syndrome [DOID:14515]

A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

Synonyms:  WAGR syndrome,  DOID:14515,  WAGR disease,  WAGR disorder,  11p partial monosomy syndrome (disorder) ...