DISEASES

Disease-gene associations mined from literature

Human genes for neuroleptic malignant syndrome

Neuroleptic malignant syndrome [DOID:14464]

Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. It generally presents with muscle rigidity, fever, autonomic instability and cognitive changes such as delirium, and is associated with elevated creatine phosphokinase (CPK). Incidence of the disease has declined since its discovery (due to changes in prescription habits), but it is still a potential danger to patients being treated with antipsychotics. Because of its unpredictability, there is no one set course of action to treat the syndrome: generally, removal of the antipsychotic drug treatment, along with the application of supportive medical management, leads to a positive outcome.

Synonyms:  neuroleptic malignant syndrome,  DOID:14464,  neuroleptic malignant disease,  neuroleptic malignant disorder