DISEASES

Disease-gene associations mined from literature

Human genes for primary biliary cirrhosis

Primary biliary cirrhosis [DOID:12236]

Primary biliary cirrhosis, often abbreviated PBC, is an autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts (bile canaliculi) within the liver. When these ducts are damaged, bile builds up in the liver (cholestasis) and over time damages the tissue. This can lead to scarring, fibrosis and cirrhosis. It was previously thought to be a rare disease, but more recent studies have shown that it may affect up to 1 in 3–4,000 people; the sex ratio is at least 9:1 (female to male).

Synonyms:  primary biliary cirrhosis,  DOID:12236,  Cirrhosis, cholestatic,  biliary cirrhosis,  biliary cirrhosis (disorder) ...