DISEASES

Disease-gene associations mined from literature

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Human genes for carpal tunnel syndrome

Carpal tunnel syndrome [DOID:12169]

Carpal Tunnel Syndrome (CTS) is an entrapment median neuropathy, causing paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel. The pathophysiology is not completely understood but can be considered compression of the median nerve traveling through the carpal tunnel. The National Center for Biotechnology Information and highly cited older literature say the most common cause of CTS is typing. More recent research by Lozano-Calderón has cited genetics as a larger factor than use, and has encouraged caution in ascribing causality.

Synonyms:  carpal tunnel syndrome,  DOID:12169,  carpal tunnel disease,  carpal tunnel disorder,  CTS - Carpal tunnel syndrome ...

The disease associations are derived via automatic text mining of the biomedical literature and have not been manually verified. The confidence of each association is signified by stars, where ★★★★☆ is the highest confidence and ★☆☆☆☆ is the lowest.

Each disease–gene association is based on a text-mining score, which is proportional to 1) the absolute number of comentionings and 2) the ratio of observed to expected comentionings (i.e. the enrichment). These scores are normalized to z-scores by comparing them to a random background. This is represented by stars, each star corresponding to two standard deviations above the mean of the background distribution.

Developed by Sune Frankild and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.