Disease-gene associations mined from literature

Human genes for detrusor sphincter dyssynergia

Detrusor sphincter dyssynergia [DOID:12145]

Bladder sphincter dyssynergia (also known as detrusor sphincter dysynergia (DSD) (the ICS standard terminology agreed 1998) and neurogenic detrusor overactivity (NDO)) is a consequence of a neurological pathology such as spinal injury or multiple sclerosis that disrupts central nervous system regulation of the micturition (urination) reflex resulting in dyscoordination of the detrusor muscles of the bladder and the external urethral sphincter muscles. In normal lower urinary tract function, these two separate muscle structures act in synergistic coordination. But in this neurogenic disorder, the urethral sphincter muscle, instead of relaxing completely during voiding, dyssynergically contracts causing the flow to be interrupted and the bladder pressure to rise. On cystography there is an irregular appearance of the bladder outline due to muscular contraction against the unrelaxed bladder sphincter.

Synonyms:  detrusor sphincter dyssynergia,  DOID:12145,  Detrusor and sphincter dyssynergia (disorder),  Detrusor and sphincter dyssynergia disorder,  Detrusor and sphincter dyssynergia