Disease-gene associations mined from literature

Human genes for tethered spinal cord syndrome

Tethered spinal cord syndrome [DOID:1089]

Tethered spinal cord syndrome or occult spinal dysraphism sequence refers to a group of neurological disorders related to malformations of the spinal cord. The various forms include: tight filum terminale, lipomeningomyelocele, split cord malformations, dermal sinus tracts, dermoids, and cystoceles. All of the forms have in common the pulling of the spinal cord at the base of the spinal canal, literally a "tethered cord". The spinal cord normally hangs loose in the canal, free to move up and down with growth and bending and stretching, a tethered cord is held taut at the end. In children, a tethered cord can cause the spinal cord to stretch as they grow, in adults the spinal cord will stretch in the course of normal activity, usually leading to progressive spinal cord damage if left untreated. It is often associated with the closure of a spina bifida, although not always depending on the form it takes; for example it can be congenital such as in tight filum terminale, or the result of injury later in life.

Synonyms:  tethered spinal cord syndrome,  DOID:1089,  tethered spinal cord disease,  tethered spinal cord disorder,  spinal dysraphism