Human genes for thrombotic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura [DOID:10772]
Thrombotic thrombocytopenic purpura (TTP or Moschcowitz syndrome:822) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. These small blood clots, called thromboses, can damage many organs including the kidneys, heart and brain. In the era before effective treatment with plasma exchange, the fatality rate was about 90%. With plasma exchange, survival at six months is around 80%. Immunosuppressants, such as glucocorticoids, rituximab, cyclophosphamide, vincristine, or cyclosporine may also be used if there is relapse or recurrence following plasma exchange.
Synonyms: thrombotic thrombocytopenic purpura, DOID:10772, Moschcowitz's syndrome, TTP - Thrombotic thrombocytopenic purpura, Thrombotic microangiopathy ...