DISEASES

Disease-gene associations mined from literature

Literature on SEPTIN12

SEPTIN12 [ENSP00000268231]

Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins . Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Synonyms:  SEPTIN12,  A0A140VJU2,  K7EIJ5,  K7EP57,  K7EP92 ...

Linkouts:  STRING  Pharos  UniProt  OMIM