DISEASES

Disease-gene associations mined from literature

Literature on UTP4

UTP4 [ENSP00000327179]

U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre- ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV .

Synonyms:  UTP4,  UTP4p,  hUTP4,  H3BPD7,  H3BRM8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM