DISEASES

Disease-gene associations mined from literature

Literature on TXNRD1

TXNRD1 [ENSP00000434516]

Thioredoxin reductase 1, cytoplasmic; Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

Synonyms:  TXNRD1,  TXNRD1p,  hTXNRD1,  A0A087WSW9,  A0A087WSY9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM