DISEASES

Disease-gene associations mined from literature

Literature on NELFE

NELFE [ENSP00000364578]

Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA . ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062,; Belongs to the RRM NELF-E family.

Synonyms:  NELFE,  A0A0A0MSN9,  A0A0A0MT02,  A0A1U9X830,  A2ABK4 ...

Linkouts:  STRING  Pharos  UniProt