DISEASES

Disease-gene associations mined from literature

Literature on AKR1C3

AKR1C3 [ENSP00000369927]

Aldo-keto reductase family 1 member C3; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone; Belongs to the aldo/keto reductase family.

Synonyms:  AKR1C3,  AKR1C3p,  hAKR1C3,  A0A0A0MSS8,  P42330 ...

Linkouts:  STRING  Pharos  UniProt  OMIM