DISEASES

Disease-gene associations mined from literature

Literature on SLC12A5

SLC12A5 [ENSP00000387694]

Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation .

Synonyms:  SLC12A5,  SLC12A5p,  hSLC12A5,  A0A087X201,  A0A0D9SF89 ...

Linkouts:  STRING  Pharos  UniProt  OMIM