DISEASES

Disease-gene associations mined from literature

Literature on SRSF3

SRSF3 [ENSP00000362820]

Serine/arginine-rich splicing factor 3; Splicing factor that specifically promotes exon-inclusion during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA- binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A- containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . RNA-binding is semi-sequence specific . ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396,

Synonyms:  SRSF3,  SRSF3p,  hSRSF3,  A0A087X2D0,  B2R6F3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM