Literature on TICRR
TICRR [ENSP00000268138]
Treslin; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation; Belongs to the treslin family.
Synonyms: TICRR, H0YN97, Q7Z2Z1, H0YN97p, hH0YN97 ...