DISEASES

Disease-gene associations mined from literature

Literature on TICRR

TICRR [ENSP00000268138]

Treslin; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation; Belongs to the treslin family.

Synonyms:  TICRR,  H0YN97,  Q7Z2Z1,  H0YN97p,  hH0YN97 ...

Linkouts:  STRING  Pharos  UniProt