DISEASES

Disease-gene associations mined from literature

Literature on CMTR1

CMTR1 [ENSP00000362550]

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

Synonyms:  CMTR1,  CMTR1p,  hCMTR1,  H0Y4T0,  H0YCQ1 ...

Linkouts:  STRING  Pharos  UniProt