DISEASES

Disease-gene associations mined from literature

Literature on AGXT2

AGXT2 [ENSP00000231420]

Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Synonyms:  AGXT2,  AGXT2p,  hAGXT2,  Q9BYV1,  Q9BYV1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM