DISEASES

Disease-gene associations mined from literature

Literature on BATF3

BATF3 [ENSP00000243440]

Basic leucine zipper transcriptional factor ATF-like 3; AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross- present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. ; Belongs to the bZIP family.

Synonyms:  BATF3,  BATF3p,  hBATF3,  Q9NR55,  Q9NR55p ...

Linkouts:  STRING  Pharos  UniProt  OMIM