DISEASES

Disease-gene associations mined from literature

Literature on GRK2

GRK2 [ENSP00000312262]

Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner . Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Synonyms:  GRK2,  GRK2p,  hGRK2,  A0A0S2Z392,  ADRBK1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM