DISEASES

Disease-gene associations mined from literature

Literature on ATP2A2

ATP2A2 [ENSP00000440045]

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle . Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.

Synonyms:  ATP2A2,  ATP2A2p,  hATP2A2,  A0A0C4DH86,  A0A0S2Z3L2 ...

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