DISEASES

Disease-gene associations mined from literature

Literature on ARAP1

ARAP1 [ENSP00000377233]

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).

Synonyms:  ARAP1,  ARAP1p,  hARAP1,  A0A0A0MSJ2,  E7EU13 ...

Linkouts:  STRING  Pharos  UniProt  OMIM