Literature on TLK1
TLK1 [ENSP00000411099]
Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414,; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Synonyms: TLK1, TLK1p, hTLK1, B3KRP1, C9JWT6 ...