DISEASES

Disease-gene associations mined from literature

Literature on CCNY

CCNY [ENSP00000363836]

Cyclin-Y; Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949,

Synonyms:  CCNY,  Q8ND76,  R4GN48,  R4GNF3,  Q8ND76p ...

Linkouts:  STRING  Pharos  UniProt  OMIM