DISEASES

Disease-gene associations mined from literature

Literature on SBNO2

SBNO2 [ENSP00000354733]

Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages . Plays a role as a regulator in the proinflammatory cascade .

Synonyms:  SBNO2,  SBNO2p,  hSBNO2,  K7ENA9,  K7ERL2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM