DISEASES

Disease-gene associations mined from literature

Literature on NECTIN2

NECTIN2 [ENSP00000252483]

Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive . Probable cell adhesion protein ; Belongs to the nectin family.

Synonyms:  NECTIN2,  NECTIN2p,  hNECTIN2,  K7EK87,  K7EKE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM