Literature on RNF139
RNF139 [ENSP00000304051]
E3 ubiquitin-protein ligase RNF139; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601,
Synonyms: RNF139, RNF139p, hRNF139, E5RH85, Q8WU17 ...