DISEASES

Disease-gene associations mined from literature

Literature on AGBL3

AGBL3 [ENSP00000388275]

Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene- encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

Synonyms:  AGBL3,  AGBL3p,  hAGBL3,  F8W6Y5,  F8W7R4 ...

Linkouts:  STRING  Pharos  UniProt