DISEASES

Disease-gene associations mined from literature

Literature on NR2C1

NR2C1 [ENSP00000333275]

Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Synonyms:  NR2C1,  NR2C1p,  hNR2C1,  A0A087WUK4,  F8W1Q1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM