DISEASES

Disease-gene associations mined from literature

Literature on ICOS

ICOS [ENSP00000319476]

Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes (By similarity).

Synonyms:  ICOS,  Q53QY6,  Q9Y6W8,  Q53QY6p,  hQ53QY6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM