DISEASES

Disease-gene associations mined from literature

Literature on DKK4

DKK4 [ENSP00000220812]

Dickkopf-related protein 4 short form; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Synonyms:  DKK4,  DKK4p,  hDKK4,  Q9UBT3,  Q9UBT3p ...

Linkouts:  STRING  Pharos  UniProt  OMIM