DISEASES

Disease-gene associations mined from literature

Literature on MED25

MED25 [ENSP00000326767]

Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.

Synonyms:  MED25,  MED25p,  hMED25,  A0A087WTR5,  A0A087WW16 ...

Linkouts:  STRING  Pharos  UniProt  OMIM