DISEASES

Disease-gene associations mined from literature

Literature on ZMYND11

ZMYND11 [ENSP00000371003]

Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA . Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Synonyms:  ZMYND11,  ZMYND11p,  hZMYND11,  A0A0A0MRY2,  B0QZE2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM