DISEASES

Disease-gene associations mined from literature

Literature on MCC

MCC [ENSP00000386227]

Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity . ; Belongs to the MCC family.

Synonyms:  A0A096LNU0,  A0A096LPB3,  D6REY2,  P23508,  D6REY2p ...

Linkouts:  STRING  Pharos  UniProt  OMIM