DISEASES

Disease-gene associations mined from literature

Literature on PLPP2

PLPP2 [ENSP00000329697]

Phospholipid phosphatase 2; Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P . Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly . Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9607309,

Synonyms:  PLPP2,  PLPP2p,  hPLPP2,  A0A0J9YXA3,  K7EMK9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM