DISEASES

Disease-gene associations mined from literature

Literature on PPP2R5C

PPP2R5C [ENSP00000412324]

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

Synonyms:  PPP2R5C,  PPP2R5Cp,  hPPP2R5C,  G3V292,  G3V2U3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM