DISEASES

Disease-gene associations mined from literature

Literature on PRODH2

PRODH2 [ENSP00000301175]

Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L- hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Synonyms:  PRODH2,  PRODH2p,  hPRODH2,  K7EJK5,  Q9UF12 ...

Linkouts:  STRING  Pharos  UniProt