Literature on RARB
RARB [ENSP00000332296]
Retinoic acid receptor beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors . The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element . In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). ; Belongs to the nuclear hormone receptor family. NR1 subfamily.
Synonyms: RARB, D6RBI3, F1D8S6, NR1B2, P10826 ...