DISEASES

Disease-gene associations mined from literature

Literature on CDK5R1

CDK5R1 [ENSP00000318486]

Cyclin-dependent kinase 5 activator 1, p25; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Synonyms:  CDK5R1,  CDK5R1p,  hCDK5R1,  J3QRB5,  Q15078 ...

Linkouts:  STRING  Pharos  UniProt  OMIM