DISEASES

Disease-gene associations mined from literature

Literature on PLPP1

PLPP1 [ENSP00000264775]

Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P . Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes . May also have an intracellular activity to regulate phospholipid- mediated signaling pathways (By similarity). ECO:0000269|PubMed:12909631, ECO:0000269|PubMed:15461590, ECO:0000269|PubMed:17379599, ECO:0000269|PubMed:9305923,; Belongs to the PA-phosphatase related phosphoesterase family.

Synonyms:  PLPP1,  PLPP1p,  hPLPP1,  A0A024QZS3,  A0A024QZU7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM