DISEASES

Disease-gene associations mined from literature

Literature on MDM4

MDM4 [ENSP00000356150]

Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Belongs to the MDM2/MDM4 family.

Synonyms:  MDM4,  MDM4p,  hMDM4,  A0A024R990,  A0A087WTR9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM