DISEASES

Disease-gene associations mined from literature

Literature on NR3C1

NR3C1 [ENSP00000231509]

Glucocorticoid receptor; Receptor for glucocorticoids (GC) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand- dependent manner which recruits the RNA helicase UPF1 and the mRNA- decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha . Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed . Loses this transcription modulator function on its own . Has no hormone-binding activity . May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner . Directly regulates STAT1 expression in isoform Alpha-independent manner . ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, [Isoform GR-P]: Increases activity of isoform Alpha. [Isoform 10]: Has transcriptional activation activity. [Isoform Alpha-C2]: Has transcriptional activation activity. [Isoform Alpha-D1]: Has transcriptional activation activity. [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity .

Synonyms:  NR3C1,  NR3C1p,  hNR3C1,  A0A494C0P1,  D6RDA9 ...

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